Pandora, ancestress of mortal women and opener of the forbidden box, represents the principle of curiosity that initiates change. In her earlier form, Pandora was the all-giving Anesidora who arose from the earth bearing gifts of food for people and animals. In later Olympian mythology, Pandora was fashioned by the gods out of earth and water, the first woman to be created. According to Hesiod, Zeus sent her as his malicious gift to punish humanity for using Prometheus’ gift of fire. Upon opening the jar, Pandora released a host of sorrows, miseries, and plagues upon the earth and closed it just before Hope could escape. Thus, she became regarded, like the biblical Eve, as the personification of feminine evil. Astrologically, Pandora serves as an intermediary in the octave progression between Mercury and Uranus. Through her curiosity, Pandora acts an an agent of change, inviting the unexpected and opening up new possibilities. By rising from the earth, she brings to light what had previously been hidden. Pandora may signify a process of deep cleansing, purification, and healing. Pandora is a Gemini-Scorpio blend who through her unorthodox actions raises the rational intellect of Mercury to the intuitive and revolutionary Controversy . The Pandora personality is marked by a curious, restless, and rebellious nature. Stressful placements of Pandora can depict a meddling troublemaker or its opposite — the individual who resists change (“don't rock the boat”) or who covers up anything unpleasant. Conflicting aspects can be integrated by encouraging creative changes.

Pandora's aspects connect curiosity and change to the planet involved. For example, this author has Pandora conjunct Urania, the ruler of astrology. Hence, her research into the asteroids has stirred up established modes of thought in astrology, unleashing a new array of archetypes to be considered.

In synastry, Pandora contacts signify those areas where we stir up others and put them through a variety of changes.